SEARCH

SEARCH BY CITATION

Keywords:

  • carbene ligands;
  • carboxylation;
  • C[BOND]H activation;
  • copper catalysts;
  • N heterocycles
Thumbnail image of graphical abstract

Greenhouse gas makes good: A simple copper-mediated protocol has been developed where N[BOND]H or C[BOND]H bonds can be directly functionalized using an easily prepared catalyst. The novel [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) hydroxide, [Cu(IPr)(OH)], permits the facile activation and carboxylation of N[BOND]H and C[BOND]H bonds with pKa values of less than 27.7 (see scheme).