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Carboxylation of N[BOND]H/C[BOND]H Bonds Using N-Heterocyclic Carbene Copper(I) Complexes


  • The EPSRC and the ERC (FUNCAT- Advanced Investigator Award to S.P.N.) are gratefully acknowledged for support of this work. Chemetall are thanked for their generous gift of materials. S.P.N. is a Royal Society Wolfson Research Merit Award holder.


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Greenhouse gas makes good: A simple copper-mediated protocol has been developed where N[BOND]H or C[BOND]H bonds can be directly functionalized using an easily prepared catalyst. The novel [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) hydroxide, [Cu(IPr)(OH)], permits the facile activation and carboxylation of N[BOND]H and C[BOND]H bonds with pKa values of less than 27.7 (see scheme).