The Third Hydrogenase: A Ferracyclic Carbamoyl with Close Structural Analogy to the Active Site of Hmd


  • P.J.T. thanks the University of East Anglia for funding; J.A.W. thanks the BBSRC for funding; J.N.T.P. thanks the EPSRC for funding.


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Natural model: The synthesis of a close structural analogue of the active site of [Fe]-hydrogenase is described (see structure; C gray, H dark blue, Fe green, N light blue, O red, S yellow). Nature most probably constructs the five membered ferracyclic ring to poise the 2-hydroxy pyridine substituent in a position to assist the heterolytic cleavage of dihydrogen, and the accessibility of the analogue should now provide opportunities for probing this.