An Enzyme-Responsive Polymeric Superamphiphile

Authors

  • Chao Wang,

    1. Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (86) 10-62771149
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  • Qishui Chen,

    1. Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (86) 10-62771149
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  • Prof. Zhiqiang Wang,

    1. Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (86) 10-62771149
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  • Prof. Xi Zhang

    1. Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China), Fax: (86) 10-62771149
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  • This work was financially supported by the National Basic Research Program (2007CB808000), the NSFC (50973051, 20974059), an NSFC–DFG joint grant (TRR 61), and the Tsinghua University Initiative Scientific Research Program (2009THZ02230). The authors acknowledge Prof. A. V. Kabanov at the University of Nebraska Medical Center for providing the PEG-b-PLKC samples. The authors acknowledge the help of Prof. Lidong Li and Fu Tang at the University of Science & Technology Beijing with DLS experiments. The authors also acknowledge the help of Prof. Fei Sun and Dr. Gang Ji with cryo-TEM.

Abstract

original image

Responding to treatment: A superamphiphile is formed between a double-hydrophilic polymer (methoxy-poly(ethylene glycol)-block-poly(L-lysine hydrochloride)) and a natural enzyme-responsive molecule (adenosine 5′-triphosphate). The superamphiphile self-assembles into spherical aggregates, which, upon addition of enzymes, disassemble and release loaded molecules (see picture).

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