Responding to treatment: A superamphiphile is formed between a double-hydrophilic polymer (methoxy-poly(ethylene glycol)-block-poly(L-lysine hydrochloride)) and a natural enzyme-responsive molecule (adenosine 5′-triphosphate). The superamphiphile self-assembles into spherical aggregates, which, upon addition of enzymes, disassemble and release loaded molecules (see picture).
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