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Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry


  • This work was supported by the National Institutes of Health (NS062725, CA147831, and AG029574). We thank the Keck Imaging Center and the Center of Nanotechnology at the University of Washington for use of their facilities.


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All aboard! A facile conjugation method allows covalent linking of functional molecules to semiconducting polymer dots for bioorthogonal labeling of cellular targets. Targeting of the polymer dots to newly synthesized proteins and glycoproteins in mammalian cells by click chemistry is highly efficient and specific.