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Keywords:

  • alkenes;
  • amines;
  • enantioselectivity;
  • intermolecular hydroamination;
  • rare-earth metals
Thumbnail image of graphical abstract

A hard nut to crack: The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare-earth-metal catalysts with up to 61 % ee and 73 % de in the case where R2 contains a stereogenic center.