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Asymmetric Intermolecular Hydroamination of Unactivated Alkenes with Simple Amines

Authors


  • This work was supported by the National Science Foundation through an NSF CAREER Award (CHE 0956021).

Abstract

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A hard nut to crack: The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare-earth-metal catalysts with up to 61 % ee and 73 % de in the case where R2 contains a stereogenic center.

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