These authors contributed equally to this work.
Mechanism of Glucose Isomerization Using a Solid Lewis Acid Catalyst in Water†
Article first published online: 20 OCT 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 47, pages 8954–8957, November 15, 2010
How to Cite
Román-Leshkov, Y., Moliner, M., Labinger, J. A. and Davis, M. E. (2010), Mechanism of Glucose Isomerization Using a Solid Lewis Acid Catalyst in Water. Angew. Chem. Int. Ed., 49: 8954–8957. doi: 10.1002/anie.201004689
This work was financially supported as part of the Catalysis Center for Energy Innovation, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DE-SC00010004. M.M. acknowledges Fundación Ramón Areces Postdoctoral Research Fellowship Program for financial support.
- Issue published online: 11 NOV 2010
- Article first published online: 20 OCT 2010
- Manuscript Received: 29 JUL 2010
- U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Grant Number: DE-SC00010004
- biomass conversion;
- glucose isomerization;
- NMR spectroscopy;
- solid Lewis acids;
Other way round: 1H and 13C NMR spectroscopy on isotopically labeled glucose reveals that in the presence of tin-containing zeolite Sn-Beta, the isomerization reaction of glucose in water proceeds by way of an intramolecular hydride shift (see scheme) rather than proton transfer. This is the first mechanistic demonstration of Sn-Beta acting as a Lewis acid in a purely aqueous environment.