We acknowledge support from the National Science Foundation (CHE-0718250). N.C. acknowledges support from NSF REU grant CHE-0754639.
Regioselective Nickel-Catalyzed Reductive Couplings of Enones and Allenes†
Article first published online: 7 OCT 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 46, pages 8712–8716, November 8, 2010
How to Cite
Li, W., Chen, N. and Montgomery, J. (2010), Regioselective Nickel-Catalyzed Reductive Couplings of Enones and Allenes. Angew. Chem. Int. Ed., 49: 8712–8716. doi: 10.1002/anie.201004740
- Issue published online: 3 NOV 2010
- Article first published online: 7 OCT 2010
- Manuscript Received: 30 JUL 2010
- National Science Foundation. Grant Number: CHE-0718250
- NSF REU. Grant Number: CHE-0754639
- conjugate addition;
- reductive coupling;
Alkenes made easy: In a complement to coupling processes of terminal alkynes, the reductive coupling of enones and allenes provides access to conjugate addition products that possess a 1,1-disubstituted alkene (see scheme; cod=1,5-cyclooctadiene). The solvent composition and reducing agent must be carefully matched to allow high levels of regioselectivity to be observed.