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Regioselective Nickel-Catalyzed Reductive Couplings of Enones and Allenes


  • We acknowledge support from the National Science Foundation (CHE-0718250). N.C. acknowledges support from NSF REU grant CHE-0754639.


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Alkenes made easy: In a complement to coupling processes of terminal alkynes, the reductive coupling of enones and allenes provides access to conjugate addition products that possess a 1,1-disubstituted alkene (see scheme; cod=1,5-cyclooctadiene). The solvent composition and reducing agent must be carefully matched to allow high levels of regioselectivity to be observed.