Communication

Strain-Controlled Release of Molecules from Arrayed Microcapsules Supported on an Elastomer Substrate†

  1. Dong Choon Hyun1,
  2. Geon Dae Moon1,
  3. Choo Jin Park1,
  4. Bong Soo Kim1,
  5. Prof. Younan Xia1,2,
  6. Prof. Unyong Jeong1,*

Article first published online: 12 NOV 2010

DOI: 10.1002/anie.201004838

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 3, pages 724–727, January 17, 2011

Additional Information

How to Cite

Hyun, D. C., Moon, G. D., Park, C. J., Kim, B. S., Xia, Y. and Jeong, U. (2011), Strain-Controlled Release of Molecules from Arrayed Microcapsules Supported on an Elastomer Substrate. Angew. Chem. Int. Ed., 50: 724–727. doi: 10.1002/anie.201004838

Author Information

  1. 1

    Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-dong, Seoul (Korea)

  2. 2

    Department of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO63130 (USA)

*Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-dong, Seoul (Korea)

  1. †

    This work was supported in part by the DAPA&ADD and by a National Research Foundation (NRF) grant funded by the Korean Government (MEST) through the Active Polymer Center Pattern Integration (No. R11-2007-050-01004-0) and by the World Class University Program (R32-20031).

Publication History

  1. Issue published online: 12 JAN 2011
  2. Article first published online: 12 NOV 2010
  3. Manuscript Revised: 25 SEP 2010
  4. Manuscript Received: 4 AUG 2010

Funded by

  • Korean Government (MEST). Grant Number: R11-2007-050-01004-0
  • World Class University Program. Grant Number: R32-20031

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Keywords:

  • drug delivery;
  • microarrays;
  • microcapsules;
  • strain response
Thumbnail image of graphical abstract

Performing under strain: Microcapsules arrayed on an elastomer substrate pumped out preloaded molecules upon mechanical stretching of the substrate as a result of a decrease in microcapsule volume. This technology could be applied to drug release, for example, from a flexible patch containing the drug through mechanical stimulation by opening and closing of the hand (see picture).

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