We are indebted to Prof. Robert Waymouth (Stanford University) for insightful comments and help in determining reasonable chemical structures, Dr. Antonio De Crisci (Stanford University) for suggesting the ruthenium hydrogen-transfer catalyst, and Prof. R. Graham Cooks (Purdue University) for encouraging the study of desorption electrospray ionization reactions. Financial support from the Air Force Office of Scientific Research (FA 9550-10-1-0235) is gratefully acknowledged.
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Communication
Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization†
Article first published online: 25 NOV 2010
DOI: 10.1002/anie.201004861
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Perry, R. H., Splendore, M., Chien, A., Davis, N. K. and Zare, R. N. (2011), Detecting Reaction Intermediates in Liquids on the Millisecond Time Scale Using Desorption Electrospray Ionization. Angew. Chem. Int. Ed., 50: 250–254. doi: 10.1002/anie.201004861
- †
Publication History
- Issue published online: 28 DEC 2010
- Article first published online: 25 NOV 2010
- Manuscript Revised: 14 SEP 2010
- Manuscript Received: 4 AUG 2010
Funded by
- Air Force Office of Scientific Research. Grant Number: FA 9550-10-1-0235
Keywords:
- mass spectrometry;
- organometallic catalysis;
- reaction intermediates;
- ruthenium;
- transfer hydrogenation
Capturing transient species: The bombardment of a surface-bound RuII complex with charged droplets containing a ligand allows the detection of reaction intermediates (see figure). The reaction investigated is used to synthesize RuII catalysts containing amino alcohol ligands, which facilitate the asymmetric transfer hydrogenation of ketones and imines.