These authors contributed equally to this work.
Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug Release†
Article first published online: 16 NOV 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 51, pages 9960–9964, December 17, 2010
How to Cite
Lee, S.-M., Song, Y., Hong, B. J., MacRenaris, K. W., Mastarone, D. J., O'Halloran, T. V., Meade, T. J. and Nguyen, S. T. (2010), Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug Release. Angew. Chem. Int. Ed., 49: 9960–9964. doi: 10.1002/anie.201004867
This work is financially supported by the NIH (NCI Center of Cancer Nanotechnology Excellence Grant U54 A119341 and Core Grant P30 A060553 to the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and award number R01EB005866 from the National Institutes of Biomedical Imaging and Bioengineering). B.J.H. is partially supported by the National Research Foundation of Korea (NRF-2009-352-C00088).
- Issue published online: 14 DEC 2010
- Article first published online: 16 NOV 2010
- Manuscript Received: 5 AUG 2010
- NIH. Grant Numbers: U54 A119341, P30 A060553
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Grant Number: R01EB005866
- National Institutes of Biomedical Imaging and Bioengineering
- National Research Foundation of Korea. Grant Number: NRF-2009-352-C00088
- antitumor agents;
- drug delivery;
- magnetic resonance imaging
Polymer-caged nanobins (PCNs) that can undergo Cu(I)-catalyzed click reactions enable the combination of GdIII magnetic resonance imaging (MRI) contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform (see picture). The resulting gadolinium(III)-conjugated, GMC-loaded PCNs (GdIII–PCNGMC) exhibit a significantly superior performance in r1 relaxivity, drug uptake, and pH-sensitive drug release.