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Keywords:

  • controlled release;
  • disulfides;
  • drug delivery;
  • nanoparticles;
  • redox chemistry
Thumbnail image of graphical abstract

If the cap fits: Attachment of collagen (Col) to silica nanoparticles (MSN) by a disulfide linker, followed by introduction of lactobionic acid (LA, a cell-specific targeting moiety), results in a redox-responsive system for cell-specific intracellular drug delivery and efficient endocytosis (see picture). Controlled release of a model drug (fluorescein isothiocyanate, FITC) was achieved by cleavage of the disufide bonds.