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Mesoporous Silica Nanoparticles End-Capped with Collagen: Redox-Responsive Nanoreservoirs for Targeted Drug Delivery


  • This work was financially supported by the Fundamental Research Funds for the Central Universities (project no. CDJZR 10 23 88 01).


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If the cap fits: Attachment of collagen (Col) to silica nanoparticles (MSN) by a disulfide linker, followed by introduction of lactobionic acid (LA, a cell-specific targeting moiety), results in a redox-responsive system for cell-specific intracellular drug delivery and efficient endocytosis (see picture). Controlled release of a model drug (fluorescein isothiocyanate, FITC) was achieved by cleavage of the disufide bonds.