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Keywords:

  • C[BOND]C coupling;
  • homogeneous catalysis;
  • palladium;
  • regioselectivity;
  • thiophenes
Thumbnail image of graphical abstract

Open access: The normally less-reactive β position of thiophenes was previously inaccessible to direct functionalization. However, the β selectivity observed with the catalytic system PdCl2/P{OCH(CF3)2}3/Ag2CO3 in the arylation of thiophenes with iodoarenes (see scheme) is a remarkably general phenomenon applicable to unsubstituted, monosubstituted, and disubstituted thiophene derivatives, as well as thiophene-containing fused aromatic compounds.