• Open Access

Electrostatic Stabilization of a Native Protein Structure in the Gas Phase


  • Funding was provided by the Austrian Science Fund (FWF): Y372 to K.B. and P19428 to M.T.


original image

One, two, three, whee! After transfer into the gas phase, the three-helix bundle protein KIX is sufficiently stabilized by electrostatic interactions to compensate for the loss of hydrophobic bonding. It thus retains its global fold on a timescale of more than 4 s.