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Communication

pH-Responsive Release of Acetal-Linked Melittin from SBA-15 Mesoporous Silica†

  1. Dr. Axel Schlossbauer1,
  2. Christian Dohmen2,
  3. Dr. David Schaffert2,
  4. Prof. Dr. Ernst Wagner2,
  5. Prof. Dr. Thomas Bein1,*

Article first published online: 17 JUN 2011

DOI: 10.1002/anie.201005120

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 30, pages 6828–6830, July 18, 2011

Additional Information

How to Cite

Schlossbauer, A., Dohmen, C., Schaffert, D., Wagner, E. and Bein, T. (2011), pH-Responsive Release of Acetal-Linked Melittin from SBA-15 Mesoporous Silica. Angew. Chem. Int. Ed., 50: 6828–6830. doi: 10.1002/anie.201005120

Author Information

  1. 1

    Department of Chemistry and Center for Nanoscience, University of Munich (LMU), Butenandtstrasse 5-13, 81377 München (Germany), Fax: (+49) 89-2180-77622 http://bein.cup.uni-muenchen.de

  2. 2

    Department of Pharmacy and Center for Nanoscience, Butenandtstrasse 5-13, 81377 München (Germany)

*Department of Chemistry and Center for Nanoscience, University of Munich (LMU), Butenandtstrasse 5-13, 81377 München (Germany), Fax: (+49) 89-2180-77622 http://bein.cup.uni-muenchen.de

  1. †

    This work was funded by the DFG through the cluster “Nanosystems Initiative Munich” and the SFB 749.

Publication History

  1. Issue published online: 13 JUL 2011
  2. Article first published online: 17 JUN 2011
  3. Manuscript Revised: 23 MAR 2011
  4. Manuscript Received: 16 AUG 2010

Funded by

  • DFG. Grant Number: SFB 749

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Keywords:

  • drug delivery;
  • host–guest systems;
  • mesoporous materials;
  • nanostructures;
  • peptides
Thumbnail image of graphical abstract

Free to go: A pH-labile immobilization of the melittin peptide with acetal linkers in the pore system of a SBA-15 host allows release of the peptide upon decrease of the pH value from 7.4 to 5.5. Such a release is shown by melittin-induced lysis of mouse erythrocytes. The method could be used to prepare new silica-based peptide delivery systems for targeted cancer therapy.

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