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Quaternary Carbon Stereogenic Centers through Copper-Catalyzed Enantioselective Allylic Substitutions with Readily Accessible Aryl- or Heteroaryllithium Reagents and Aluminum Chlorides


  • The NIH (GM-47480) provided financial support. Y.L. is grateful for an AstraZeneca graduate fellowship. Mass spectrometry facilities at Boston College are supported by the NSF (CHE-0619576).


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The case of the notorious aryls is solved: The first efficient catalytic and enantioselective method for allylic substitutions that furnish quaternary carbon stereogenic centers by additions of aryl- or heteroarylmetals is reported (see scheme). Highly site- and enantioselective processes begin with readily available organolithium reagents.