The Largest Synthetic Structure with Molecular Precision: Towards a Molecular Object


  • We thank the ETH Zürich, and the Swiss National Science Foundation (NRP 62 “Smart Materials” and SCOPES IZ73Z0-128169) for financial support.


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Pushing the limits: A 200×106 Da structurally defined, linear macromolecule (PG5) has a molar mass, cross-section dimension, and cylindrical shape that are comparable to some naturally occurring objects, such as amyloid fibrils or certain plant viruses. The macromolecule is resistant against flattening out on a surface; the picture shows PG5 embracing the tobacco mosaic virus (TMV).