This study was supported by the Department of Science and Technology (DST), New Delhi. G.M. acknowledges the DST for the award of Ramanna and Swarnajayanti fellowships and D.M. thanks the Indian Institute of Science for a fellowship. We thank Prof. Josef Köhrle for helpful discussions.
A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase†
Article first published online: 12 OCT 2010
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 49, Issue 48, pages 9246–9249, November 22, 2010
How to Cite
Manna, D. and Mugesh, G. (2010), A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase. Angew. Chem. Int. Ed., 49: 9246–9249. doi: 10.1002/anie.201005235
- Issue published online: 17 NOV 2010
- Article first published online: 12 OCT 2010
- Manuscript Received: 21 AUG 2010
- Indian Institute of Science
- enzyme models;
The I of the beholder: The presented chemical model for the inner-ring deiodination of thyroxine (T4) and 3,5,3′-triiodothyronine (T3) by iodothyronine deiodinase (see scheme) highlights the importance of an in-built thiol group in proximity to the selenium atom. The effective removal of iodine in the case of T4 indicates that an enol–keto tautomerism is not required for deiodination.