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A Chemical Model for the Inner-Ring Deiodination of Thyroxine by Iodothyronine Deiodinase


  • This study was supported by the Department of Science and Technology (DST), New Delhi. G.M. acknowledges the DST for the award of Ramanna and Swarnajayanti fellowships and D.M. thanks the Indian Institute of Science for a fellowship. We thank Prof. Josef Köhrle for helpful discussions.


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The I of the beholder: The presented chemical model for the inner-ring deiodination of thyroxine (T4) and 3,5,3′-triiodothyronine (T3) by iodothyronine deiodinase (see scheme) highlights the importance of an in-built thiol group in proximity to the selenium atom. The effective removal of iodine in the case of T4 indicates that an enol–keto tautomerism is not required for deiodination.

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