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Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson’s Disease with Semisynthetic Ubiquitinated α-Synuclein

Authors


  • This research was supported by an ERC starting grant (H.L., M.H., 243182), the Edmond J. Safra Foundation, and partially supported by a Human Science Frontiers Young Investigator Grant (H.L. and A.B). We thank Dr. Sara Butterfield and Bruno Fauvet for insightful discussions.

Abstract

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Ubiquitinate me here: The semisynthesis and characterization of a site-specifically monoubiquitinated form of α-synuclein (see picture) enabled investigation of the effect of ubiquitination on membrane binding, oligomerization, and fibrillogenesis. The introduction of specific ubiquitin modifications into α-synuclein will shed light on the role of ubiquitination in regulating the function(s) of α-synuclein in health and disease.

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