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Keywords:

  • alkane activation;
  • cytochromes;
  • oxidative biocatalysis;
  • protein engineering;
  • sustainable chemistry
Thumbnail image of graphical abstract

Going green: Chemical methods for the hydroxylation of alkanes involve toxic, dangerous reagents and are not very selective. In a biochemical alternative route based on an artificial self-sufficient cytochrome P450, the highly selective and efficient terminal hydroxylation of n-alkanes is possible under mild conditions (see scheme; NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate (NADP+)).