Relevant Anion–π Interactions in Biological Systems: The Case of Urate Oxidase

Authors

  • Carolina Estarellas,

    1. Departament de Química, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, Palma de Mallorca (Spain), Fax: (+34) 971-173-426
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  • Prof. Antonio Frontera,

    Corresponding author
    1. Departament de Química, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, Palma de Mallorca (Spain), Fax: (+34) 971-173-426
    • Departament de Química, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, Palma de Mallorca (Spain), Fax: (+34) 971-173-426
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  • Dr. David Quiñonero,

    1. Departament de Química, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, Palma de Mallorca (Spain), Fax: (+34) 971-173-426
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  • Prof. Dr. Pere M. Deyà

    1. Departament de Química, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, Palma de Mallorca (Spain), Fax: (+34) 971-173-426
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  • We thank the DGICYT of Spain (project CTQ2008-00841/BQU, FEDER funds) for financial support. We thank the CESCA for computational facilities. C.E. thanks the MEC of Spain for a predoctoral fellowship. D.Q. thanks the MICINN of Spain for a “Ramón y Cajal” contract.

Abstract

original image

Enzyme inhibited: The important role of anion–π interactions that are present in the active site of the urate oxidase enzyme is reported (see picture). The inhibition of this enzyme by cyanide ions is caused by the existence of an anion–π interaction between the inhibitor and the enzymatic substrate. This investigation extends the relevance of anion–π interactions to important fields such as enzyme chemistry.

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