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Self-Immobilizing Fluorogenic Imaging Agents of Enzyme Activity


  • K.R. is a recipient of a PhD scholarship from the Commission on Higher Education, Thailand.


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Lighting up enzyme activity: Fluorogenic enzyme substrates have been developed that upon hydrolysis form reactive quinone methides, which can react with cell components in vivo to generate an immobilized fluorescent label (see scheme). These compounds can be used for the histological staining of tissues or activity-based screening of cells by fluorescence-activated cell sorting.

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