Communication

Delivery of Intact Transcription Factor by Using Self-Assembled Supramolecular Nanoparticles†

  1. Yang Liu1,2,3,4,
  2. Dr. Hao Wang1,*,
  3. Dr. Ken-ichiro Kamei1,5,
  4. Dr. Ming Yan2,
  5. Kuan-Ju Chen1,
  6. Qinghua Yuan5,
  7. Prof. Linqi Shi3,4,*,
  8. Prof. Yunfeng Lu2,*,
  9. Prof. Hsian-Rong Tseng1,*

Article first published online: 2 MAR 2011

DOI: 10.1002/anie.201005740

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 13, pages 3058–3062, March 21, 2011

Additional Information

How to Cite

Liu, Y., Wang, H., Kamei, K.-i., Yan, M., Chen, K.-J., Yuan, Q., Shi, L., Lu, Y. and Tseng, H.-R. (2011), Delivery of Intact Transcription Factor by Using Self-Assembled Supramolecular Nanoparticles. Angewandte Chemie International Edition, 50: 3058–3062. doi: 10.1002/anie.201005740

Author Information

  1. 1

    Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770 (USA) http://labs.pharmacology.ucla.edu/tsenglab/

  2. 2

    Department of Chemical & Biomolecular Engineering, University of California, Los Angeles, 420 Westwood Plaza, BH5573G, Los Angeles, CA 90095 (USA) http://www.seas.ucla.edu/∼lu/

  3. 3

    Key Laboratory of Functional Polymer Materials, Ministry of Education (China)

  4. 4

    Institute of Polymer Chemistry and Physics, Nankai University, Tianjin (China)

  5. 5

    Institute for Integrated Cell-Material Sciences, Kyoto University (Japan)

*Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California, Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770 (USA) http://labs.pharmacology.ucla.edu/tsenglab/

  1. †

    This research was supported by National Institutes of Health (NIH), Defense Threat Reducing Agency (DTRA), and National Science Foundation of China, NSFC (50625310 and 50830103).

Publication History

  1. Issue published online: 15 MAR 2011
  2. Article first published online: 2 MAR 2011
  3. Manuscript Revised: 20 DEC 2010
  4. Manuscript Received: 14 SEP 2010

Funded by

  • National Institutes of Health (NIH)
  • Defense Threat Reducing Agency (DTRA)
  • National Science Foundation of China. Grant Numbers: 50625310, 50830103

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Keywords:

  • nanoparticles;
  • protein delivery;
  • self-assembly;
  • supramolecular chemistry;
  • transcription factors

Graphical Abstract

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Special delivery: A supramolecular nanoparticle provides a facile and modular protein delivery system (see picture, TAT enables cell membrane penetration, RGD targeting, and PEG passivation) for highly efficient transduction of intact (unmodified) transcription factors (TF). Such a TF delivery approach provides a powerful method for manipulating cellular behavior.

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