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A General and Selective Iron-Catalyzed Aminocarbonylation of Alkynes: Synthesis of Acryl- and Cinnamides

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  • This work was funded by the the Deutsche Forschungsgemeinschaft (Graduiertenkolleg 1213 and Leibniz-price). We thank Dr. C. Fischer, S. Buchholz, S. Schareina, A. Kammer, K. Fiedler, A. Lehmann, I. Stahr, A. Koch, and Dr. W. Baumann for their excellent technical and analytical support.

Abstract

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Entering the iron age: The first general method for iron-catalyzed monocarbonylation of alkynes has been developed. A range of structurally diverse cinnamides and acrylamides have been obtained smoothly starting from commercially available amines and alkynes in the presence of [Fe3(CO)12] and ligand L (see scheme). The method is highly chemo- and regioselective and requires no expensive catalyst.

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