Communication

Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers†

  1. Dr. Shutao Wang1,7,‡,
  2. Dr. Kan Liu2,7,‡,
  3. Dr. Jian Liu6,7,‡,
  4. Dr. Zeta T.-F. Yu7,
  5. Xiaowen Xu7,
  6. Libo Zhao7,
  7. Tom Lee7,
  8. Dr. Eun Kyung Lee7,
  9. Jean Reiss3,
  10. Prof. Yi-Kuen Lee5,
  11. Prof. Leland W. K. Chung6,
  12. Prof. Jiaoti Huang3,
  13. Prof. Matthew Rettig4,
  14. Prof. David Seligson3,
  15. Dr. Kumaran N. Duraiswamy7,*,
  16. Prof. Clifton K.-F. Shen7,*,
  17. Prof. Hsian-Rong Tseng7,*

Article first published online: 4 MAR 2011

DOI: 10.1002/anie.201005853

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 13, pages 3084–3088, March 21, 2011

Additional Information

How to Cite

Wang, S., Liu, K., Liu, J., Yu, Z. T.-F., Xu, X., Zhao, L., Lee, T., Lee, E. K., Reiss, J., Lee, Y.-K., Chung, L. W. K., Huang, J., Rettig, M., Seligson, D., Duraiswamy, K. N., Shen, C. K.-F. and Tseng, H.-R. (2011), Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers. Angew. Chem. Int. Ed., 50: 3084–3088. doi: 10.1002/anie.201005853

Author Information

  1. 1

    Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing (P. R. China)

  2. 2

    College of Electronics and Information Engineering, Wuhan Textile University, Wuhan (P. R. China)

  3. 3

    Department of Pathology and Laboratory Medicine, University of California, Los Angeles (USA)

  4. 4

    Department of Urology, University of California, Los Angeles (USA)

  5. 5

    Department of Mechanical Engineering, The Hong Kong University of Science and Technology (Hong Kong)

  6. 6

    Uro-oncology Research Program, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles (USA)

  7. 7

    Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770 (USA), Fax: (+1) 310-206-8975 http://labs.pharmacology.ucla.edu/tsenglab/

  1. ‡

    These authors contributed equally to this work.

*Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), Institute for Molecular Medicine (IMED), University of California Los Angeles, 570 Westwood Plaza, Building 114, Los Angeles, CA 90095-1770 (USA), Fax: (+1) 310-206-8975 http://labs.pharmacology.ucla.edu/tsenglab/

  1. †

    This research was supported by the NIH IMAT Program (R21A151159-01) and a Prostate Cancer Foundation Creativity Award. We thank Prof. Allan Pantuck from the UCLA Urology Department for providing CTC blood samples.

  2. ‡

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 15 MAR 2011
  2. Article first published online: 4 MAR 2011
  3. Manuscript Revised: 19 NOV 2010
  4. Manuscript Received: 18 SEP 2010

Funded by

  • NIH. Grant Number: R21A151159-01
  • Prostate Cancer Foundation Creativity Award

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Keywords:

  • cancer diagnosis;
  • cell capture;
  • circulating tumor cell;
  • microfluidics;
  • nanostructured materials
Thumbnail image of graphical abstract

Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody-coated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression.

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