These authors contributed equally to this work.
Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers†
Article first published online: 4 MAR 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 13, pages 3084–3088, March 21, 2011
How to Cite
Wang, S., Liu, K., Liu, J., Yu, Z. T.-F., Xu, X., Zhao, L., Lee, T., Lee, E. K., Reiss, J., Lee, Y.-K., Chung, L. W. K., Huang, J., Rettig, M., Seligson, D., Duraiswamy, K. N., Shen, C. K.-F. and Tseng, H.-R. (2011), Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers. Angew. Chem. Int. Ed., 50: 3084–3088. doi: 10.1002/anie.201005853
This research was supported by the NIH IMAT Program (R21A151159-01) and a Prostate Cancer Foundation Creativity Award. We thank Prof. Allan Pantuck from the UCLA Urology Department for providing CTC blood samples.
- Issue published online: 15 MAR 2011
- Article first published online: 4 MAR 2011
- Manuscript Revised: 19 NOV 2010
- Manuscript Received: 18 SEP 2010
- NIH. Grant Number: R21A151159-01
- Prostate Cancer Foundation Creativity Award
- cancer diagnosis;
- cell capture;
- circulating tumor cell;
- nanostructured materials
Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody-coated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression.