Communication

Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N-Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters†

  1. Daniel T. Cohen,
  2. Dr. Benoit Cardinal-David,
  3. Prof. Karl A. Scheidt*

Article first published online: 14 JAN 2011

DOI: 10.1002/anie.201005908

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 50, Issue 7, pages 1678–1682, February 11, 2011

Additional Information

How to Cite

Cohen, D. T., Cardinal-David, B. and Scheidt, K. A. (2011), Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N-Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters. Angew. Chem. Int. Ed., 50: 1678–1682. doi: 10.1002/anie.201005908

Author Information

  1. Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)

*Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA)

  1. †

    Financial support was generously provided by the NIH (NIGMS RO1 GM73072), Amgen, AstraZeneca, GlaxoSmithKline, and a GAANN (Graduate Assistance in Areas of Nation Need) fellowship to D.T.C. FQRNT (Fonds Québécois de la Recherche sur la Nature et les Technologies) is also gratefully acknowledged for a postdoctoral fellowship to B.C.-D. We thank John M. Roberts (NU) for assistance with X-ray crystallography.

Publication History

  1. Issue published online: 9 FEB 2011
  2. Article first published online: 14 JAN 2011
  3. Manuscript Revised: 2 DEC 2010
  4. Manuscript Received: 20 SEP 2010

Funded by

  • NIH. Grant Number: NIGMS RO1 GM73072

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View Full Article with Supporting Information (HTML) Get PDF (385K)