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Keywords:

  • aldol reactions;
  • organocatalysis;
  • regioselectivity;
  • synthetic methods;
  • vinylogy
Thumbnail image of graphical abstract

Let's talk about six! A new chiral disulfonimide catalyzed vinylogous Mukaiyama aldol addition of crotonic acid derived nucleophiles to aldehydes has been developed and the concept of vinylogy was further expanded to double vinylogous, sorbic acid derived nucleophiles. This reaction is an example of a previously unknown ε-selective bisvinylogous Mukaiyama Aldol addition that extends the substrate by six carbon atoms (see scheme).