SEARCH

SEARCH BY CITATION

Keywords:

  • electrophilic addition;
  • hypervalent compounds;
  • nitrogen heterocycles;
  • synthetic methods;
  • trifluoromethylation
Thumbnail image of graphical abstract

Acid-catalyzed electrophilic trifluoromethylation of nitriles in the presence of azoles leads to N-(trifluoromethyl)imine derivatives. The source of the trifluoromethyl group is a readily prepared and easy-to-handle hypervalent iodine(III) reagent (see scheme; HNTf2=bis(N-(trifluoromethanesulfonyl)imide). This Ritter-type reaction is astraightforward approach to N-(trifluoromethyl)imidoyl azoles, compounds otherwise very difficult to access.