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Stabilization of Virus-like Particles with Poly(2-oxazoline)s


  • This work was supported by the NIH (CA112075, RR021886), the Skaggs Institute for Chemical Biology, the W. M. Keck Foundation, the International Graduate School of Science and Engineering and the CompInt (TU München), the Postdoc Programe of the German Academic Exchange Service (DAAD) (fellowship for F.M.), the King Abdullah University of Science and Technology (KAUST Award No. KUK-F1-029-32, partial salary support for R.L.), and the Deutsche Forschungsgemeinschaft (grant to M.R.). We thank Dr. Malcolm Wood for assistance with TEM images and Prof. H. Kitagishi, Dr. S. D. Brown, V. Hong, and Dr. J.-K. Rhee for helpful discussions.


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Wrap it up! Highly efficient copper-catalyzed click chemistry can cover virus-like particles with functionalized poly(2-oxazoline) chains without interparticle aggregation. The resulting core–shell structures are significantly more temperature-stable than the native protein particles.