We thank A. Perner, H. Heinecke, and F. Rhein for MS and NMR measurements, U. Valentin for SPE, C. Heiden and M. Steinacker for fermentation and downstream processing, and C. Weigel for performing biological assays. This research was financially supported by the Federal Ministry of Science and Technology (BMBF, Germany).
Divergolides A–D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis†
Article first published online: 11 JAN 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 7, pages 1630–1634, February 11, 2011
How to Cite
Ding, L., Maier, A., Fiebig, H.-H., Görls, H., Lin, W.-H., Peschel, G. and Hertweck, C. (2011), Divergolides A–D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa-Macrolide Biosynthesis. Angew. Chem. Int. Ed., 50: 1630–1634. doi: 10.1002/anie.201006165
- Issue published online: 9 FEB 2011
- Article first published online: 11 JAN 2011
- Manuscript Received: 1 OCT 2010
- Federal Ministry of Science and Technology
- natural products;
- structure elucidation
In-built diversification: Four ansa macrolides, divergolides A–D (1–4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.