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Keywords:

  • ansamycins;
  • macrolides;
  • natural products;
  • polyketides;
  • structure elucidation
Thumbnail image of graphical abstract

In-built diversification: Four ansa macrolides, divergolides A–D (14), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties.