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Keywords:

  • azides;
  • continuous-flow synthesis;
  • microreactors;
  • synthetic methods;
  • tetrazoles
Thumbnail image of graphical abstract

Safer flow: The synthesis of 5-substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near-equimolar amount of NaN3, yet nonetheless displays a broad substrate scope. The hazards associated with HN3 are essentially eliminated, shock-sensitive metal azides such as Zn(N3)2 are avoided, and residual NaN3 is quenched in-line with NaNO2.