Generous support from the Max-Planck-Society, the DFG (Priority Program Organocatalysis SPP1179), and the Fonds der Chemischen Industrie is gratefully acknowledged. We also thank our HPLC and GC departments for their support.
The Catalytic Asymmetric Knoevenagel Condensation†
Article first published online: 20 JAN 2011
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 50, Issue 7, pages 1707–1710, February 11, 2011
How to Cite
Lee, A., Michrowska, A., Sulzer-Mosse, S. and List, B. (2011), The Catalytic Asymmetric Knoevenagel Condensation. Angew. Chem. Int. Ed., 50: 1707–1710. doi: 10.1002/anie.201006319
- Issue published online: 9 FEB 2011
- Article first published online: 20 JAN 2011
- Manuscript Received: 8 OCT 2010
- Fonds der Chemischen Industrie
- α-branched aldehydes;
- dynamic kinetic resolution;
- Knoevenagel condensation;
116 years after the discovery of the Knoevenagel condensation, the first catalytic asymmetric variant has been developed. Dynamic kinetic resolution in the reaction of α-branched aldehydes with malonates in the presence of a newly designed and readily available modified cinchona amine catalyst gives the corresponding alkylidene malonates in high enantioselectivity (see scheme).