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Keywords:

  • α-branched aldehydes;
  • dynamic kinetic resolution;
  • enantioselectivity;
  • Knoevenagel condensation;
  • organocatalysis
Thumbnail image of graphical abstract

116 years after the discovery of the Knoevenagel condensation, the first catalytic asymmetric variant has been developed. Dynamic kinetic resolution in the reaction of α-branched aldehydes with malonates in the presence of a newly designed and readily available modified cinchona amine catalyst gives the corresponding alkylidene malonates in high enantioselectivity (see scheme).