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Single-Molecule Detection of Proteins Using Aptamer-Functionalized Molecular Electronic Devices

Authors

  • Song Liu,

    1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P. R. China), Fax: (+86) 10-6275-7789
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    • These authors contributed equally to the work.

  • Xinyue Zhang,

    1. Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P. R. China)
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    • These authors contributed equally to the work.

  • Wangxi Luo,

    1. Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P. R. China)
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  • Zhenxing Wang,

    1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P. R. China), Fax: (+86) 10-6275-7789
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  • Prof. Xuefeng Guo,

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P. R. China), Fax: (+86) 10-6275-7789
    • Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (P. R. China), Fax: (+86) 10-6275-7789
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  • Dr. Michael L. Steigerwald,

    1. Department of Chemistry and the Columbia University Center for Electronics of Molecular Nanostructures, New York (USA)
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  • Prof. Xiaohong Fang

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P. R. China)
    • Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P. R. China)
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  • We thank Colin Nuckolls (Columbia University) and Zhongfan Liu (Peking University) for enlightening discussions. We acknowledge primary financial support from MOST (2009CB623703, 2007CB935601, 2011CB911001, and 2008AA062503), NSFC (50873004, 50821061, 20821003, and 20833001), FANEDD (2007B21), 111 Project (B08001), and BSTSP (2009A01)

Abstract

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Filling in the gap: Label-free, real-time electrical detection of proteins is achieved with high selectivity and real single-molecule sensitivity by using aptamer-functionalized molecular electronic devices with single-walled carbon nanotubes as point contacts.

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