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Keywords:

  • asymmetric catalysis;
  • directing groups;
  • hydroformylation;
  • regioselectivity;
  • scaffolding ligands
Thumbnail image of graphical abstract

A designer phosphine ligand capable of bonding covalently to an olefin substrate directed rhodium-catalyzed hydroformylation to generate branched aldehydes with high regio- and enantioselectivity. The use of such scaffolding ligands opens up new directions in asymmetric synthesis.