A New Direction in Enantioselective Catalysis: Scaffolding Ligands in Olefin Hydroformylation

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Abstract

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A designer phosphine ligand capable of bonding covalently to an olefin substrate directed rhodium-catalyzed hydroformylation to generate branched aldehydes with high regio- and enantioselectivity. The use of such scaffolding ligands opens up new directions in asymmetric synthesis.

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