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Rapid microRNA Profiling on Encoded Gel Microparticles


  • We gratefully acknowledge support from the National Institutes of Health and the National Cancer Institute. The content is solely the responsibility of the authors and does not necessarily represent the views of the National Institutes of Health or the National Cancer Institute. D.C.P. and P.S.D. have an equity stake in Firefly BioWorks, Inc.


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Sensitive, flexible, and rapid: A post-hybridization labeling scheme was combined with a high-throughput microfluidic scanning system to demonstrate the use of graphically encoded gel particles for rapid microRNA quantification (see picture). A versatile particle encoding scheme allows for scalable multiplexing that provides attomole sensitivity with a simple and efficient workflow.