SEARCH

SEARCH BY CITATION

Keywords:

  • alkanes;
  • C[BOND]H activation;
  • host–guest systems;
  • methane oxidation;
  • P450 enzymes
Thumbnail image of graphical abstract

A new spin: The addition of chemically inert perfluoro carboxylic acids (green; see picture) to P450 enzymes results in dramatic activation of their catalytic activity as a result of the conversion of the Fe/heme from a low-spin to a high-spin state, and the reduction of the binding-pocket size. Together these effects allow otherwise inert substrates such as propane and even methane to be oxidized.