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Zinc-Triggered Hydrogelation of a Self-Assembling β-Hairpin Peptide


  • This work was supported in part by the National Science Foundation (CHE 0348323, JPS) and the Arnold and Mabel Beckman Foundation.


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Zinc-chronized gelling: Selective zinc-triggered hydrogel formation is realized by the self-assembly of a de novo designed peptide (see picture). A non-natural, zinc-binding aminocarboxylate residue is incorporated into the peptide and is used to trigger folding, assembly, and subsequent gelation.