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Asymmetric Autocatalysis Enables an Improved Synthesis of Efavirenz


  • We thank Dr. B. Schweizer for performing the X-ray analysis.


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Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).