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Synthesis of α-Aryl Nitriles through Palladium-Catalyzed Decarboxylative Coupling of Cyanoacetate Salts with Aryl Halides and Triflates


  • We acknowledge the support of the national “973” grants from the Ministry of Science and Technology (No. 2011CB965300). We also thank The State Key Laboratory of Bio-organic and Natural Products Chemistry (CAS) and the Knowledge Innovation Program of CAS for support.


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Worth its salt: The palladium-catalyzed decarboxylative coupling of the cyanoacetate salt as well as its mono- and disubstituted derivatives with aryl chlorides, bromides, and triflates is described (see scheme). This reaction is potentially useful for the preparation of a diverse array of α-aryl nitriles and has good functional group tolerance. S-Phos=2-(2,6-dimethoxybiphenyl)dicyclohexylphosphine), Xant-Phos=4,5-bis(diphenylphosphino)-9,9-dimethylxanthene.