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Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus

Authors

  • Ming Yang,

    1. Department of Biomedical Engineering, Johns Hopkins University, Baltimore (USA)
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    • These authors contributed equally to this work.

  • Dr. Samuel K. Lai,

    1. Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore (USA)
    2. Current address: Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill (USA)
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    • These authors contributed equally to this work.

  • Ying-Ying Wang,

    1. Department of Biomedical Engineering, Johns Hopkins University, Baltimore (USA)
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  • Weixi Zhong,

    1. Department of Biomedical Engineering, Johns Hopkins University, Baltimore (USA)
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  • Christina Happe,

    1. Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore (USA)
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  • Michael Zhang,

    1. Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore (USA)
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  • Dr. Jie Fu,

    1. Department of Ophthalmology, Johns Hopkins University, Baltimore (USA)
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  • Prof. Dr. Justin Hanes

    Corresponding author
    1. Departments of Ophthalmology, Biomedical Engineering, Chemical & Biomolecular Engineering and Oncology, Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology and Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21287 (USA), Fax: (+1) 410-614-6509 http://www.jhu.edu/haneslab/
    • Departments of Ophthalmology, Biomedical Engineering, Chemical & Biomolecular Engineering and Oncology, Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology and Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21287 (USA), Fax: (+1) 410-614-6509 http://www.jhu.edu/haneslab/
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  • We thank the Integrated Imaging Center at Johns Hopkins University. This work was supported by the NIH (R21AI079740, R01A140746, R21L089816 and U54A151838), a Croucher Foundation Fellowship to S.K.L., and a National Science Foundation Graduate Research Fellowship to Y.-Y.W. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Cancer Institute.

Abstract

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Slipping through: Pluronic molecules adsorb onto nanoparticle surfaces through their polypropylene oxide (PPO) segments with the flanking polyethylene glycol (PEG) segments forming a dense muco-inert brush (see picture; top). While uncoated particles are immobilized in mucus through adhesive interactions with mucus mesh elements, coated particles diffuse rapidly through spaces in the mucus mesh (bottom).

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