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Keywords:

  • bioinorganic chemistry;
  • DNA recognition;
  • metallodrugs;
  • platinum;
  • transcription factors
Thumbnail image of graphical abstract

In the groove: The unique major-groove-binding properties of a PtII complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the PtII center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity.