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Morphological Transformation between Nanofibers and Vesicles in a Controllable Bipyridine–Tripeptide Self-Assembly

Authors

  • Damei Ke,

    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Photochemistry, Institute of Chemistry, CAS, Beijing 100190 (P.R. China), Fax: (+86) 10-8261-6517
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  • Dr. Chuanlang Zhan,

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Photochemistry, Institute of Chemistry, CAS, Beijing 100190 (P.R. China), Fax: (+86) 10-8261-6517
    • Beijing National Laboratory for Molecular Sciences, Laboratory of Photochemistry, Institute of Chemistry, CAS, Beijing 100190 (P.R. China), Fax: (+86) 10-8261-6517
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  • Prof. Dr. Alexander D. Q. Li,

    1. Department of Chemistry, Washington State University (USA)
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  • Prof. Dr. Jiannian Yao

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences, Laboratory of Photochemistry, Institute of Chemistry, CAS, Beijing 100190 (P.R. China), Fax: (+86) 10-8261-6517
    • Beijing National Laboratory for Molecular Sciences, Laboratory of Photochemistry, Institute of Chemistry, CAS, Beijing 100190 (P.R. China), Fax: (+86) 10-8261-6517
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  • This work was financially supported by NSFC (Nos. 20973182, 20872145, and 20733006), the Chinese Academy of Sciences, 973 Projects (2006CB806200 and 2007CB936401), and NSF (CHE-0805547).

Abstract

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Tuning structures: Stimulus-responsive peptide self-assembly requires a balance of conformational change and structural continuity of stable β sheets. In an amphiphilic bipyridine–tripeptide model, temperature, and ultrasound switch a reversible morphological transformation between vesicles and nanofibers (see picture) through the synergistic effects of terminal β-sheet-forming peptides, flexible linkers, and rotatable bipyridine groups.

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