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Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390

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  • This work was funded by BBSRC/EPSRC grant E021611. We thank Daiichi Sankyo Co. Ltd for funding (D.F.) and for strain SANK73390, and Dr. C. P. Butts for assistance with NMR analysis. MRSA=methicillin-resistant Staphylococcus aureus.

Abstract

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New drugs from marine bugs: The Japanese marine bacterium Pseudoalteromonas SANK73390 has been engineered to produce hybrid thiomarinol/pseudomonic acid compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). Previously unreported mupirocin and pyrrothine metabolites were isolated from wild-type and mutant strains and from mutagenesis experiments with mutant strains.

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