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Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

Authors

  • Dr. Aman A. Desai

    Corresponding author
    1. Process Chemistry and Development, Core R & D, The Dow Chemical Company, Midland, MI 48674 (USA), Fax: (+1) 989-638-7003
    • Process Chemistry and Development, Core R & D, The Dow Chemical Company, Midland, MI 48674 (USA), Fax: (+1) 989-638-7003
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  • The author is indebted to Dr. Mathew J. Vetticatt for many helpful discussions.

Abstract

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Generation gap: Three generations of process research and development towards the industrial manufacture of sitagliptin phosphate (1), a leading drug for type 2 diabetes, are highlighted.

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